We were trying to work with IBM in delivering a product on the 16-bit Series/1 (yet another competitor to the PDP-11) running a little-known version of Unix that IBM provided for the Series/1: CP/IX ("Carrier Products Interactive Executive"). It was developed at Case Western Reserve University for IBM's Telecommunication Carrier Products Division (based in Princeton, NJ, to sell to the phone companies) and was based on Unix System III. I recall going to Princeton to evaluate their implementation, taking a Berkeley source tape with me. I spent a day getting vi and csh to run. Even though the Series/1 had separate instruction and data space (like the PDP-11; 64 Kbytes for each), the Series/1 instruction set was slightly less efficient than the PDP-11s, and vi used all 64 Kbytes of instruction space on the PDP-11. It took some creative hacking to get vi running on the Series/1. We did end up getting a Series/1 for development, but gave up on it shortly thereafter, when we discovered that a PC XT (later a PC AT) running Unix was just as fast, and much cheaper. Berkeley Unix on a VAX was also a much nicer program development environment than the Series/1.
We replaced the PDP-11/23 with a VAX-11/750 running 4.2BSD, later upgrading this to a VAX-11/785. As I recall we were able to run around 16 users on a 4 Mbyte 750. Later we got a VAX-11/785 and then a VAX 8600 (upgrading the latter to an 8650). All our VAXes ran Berkeley Unix (I had seen how programmer unfriendly VMS was during my Kitt Peak days. Been there, done that.)